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Statistical analysis and reproducibility All statistical comparisons were made in GraphPad Prism 10.2.1 (GraphPad Software, San Diego, California USA, www.graphpad.com)

Furthermore, uncertainty in accounting for individual patient variability, such as genetic predispositions, disease stage, or coexisting conditions, makes available drugs less effective across diverse patient populations 78

Zu et al., indeed, demonstrated in Drosophila melanogaster that the deletion of miR-14 increased the levels of triacylglycerol and diacylglycerol while its overexpression resulted in the converse effect 94

Author Reply to TrixieG I would not recommend it since the compounds can interact with one another via their effects on blood glucose levels Reply to Daniel Louwrens BSc PT Thank you